Mesenchymal stem cells-derived exosomes for drug delivery

Y Sun, G Liu, K Zhang, Q Cao, T Liu, J Li - Stem cell research & therapy, 2021 - Springer
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid
bilayers without organelles. In recent years, an increasing number of researchers have …

The Yin and Yang of exosome isolation methods: conventional practice, microfluidics, and commercial kits

SZ Shirejini, F Inci - Biotechnology Advances, 2022 - Elsevier
Exosomes are a subset of extracellular vesicles released from various cells, and they can be
found in different bodily fluids. Exosomes have been utilized as biomarkers to diagnose …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity

L Yan, X Wu - Cell biology and toxicology, 2020 - Springer
Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an
important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based …

Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system

J Rezaie, V Nejati, M Mahmoodi, M Ahmadi - Biochemical Pharmacology, 2022 - Elsevier
An ideal drug delivery system should selectively deliver incorporated therapeutics to the
target site, escape from immune cells recognition and degradation, and act controlled …

[HTML][HTML] Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature

Y Shimizu, EH Ntege, H Sunami, Y Inoue - Regenerative therapy, 2022 - Elsevier
Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities,
and it remains an economic burden to individuals and the society. Alopecia is attributable to …

Extracellular microvesicles as new industrial therapeutic frontiers

V Agrahari, V Agrahari, PA Burnouf, CH Chew… - Trends in …, 2019 - cell.com
Microvesicles (MVs) are subcellular physiological vehicles present in all body fluids that
mediate the transfer of intercellular information within biological systems and contribute to …

Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile

R Jeske, C Liu, L Duke, MLC Castro, L Muok, P Arthur… - Bioactive Materials, 2023 - Elsevier
Human mesenchymal stromal cells (hMSCs) are mechanically sensitive undergoing
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …

Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …