The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major
contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to …

Diabesity is an abnormal metabolic condition shown by patients with obesity that develop
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …

This comprehensive review thoroughly explores the intricate involvement of insulin receptor
(IR) isoforms and insulin-like growth factor receptors (IGFRs) in the context of the insulin and …

Adenosine receptor signaling plays important roles in normal physiology, but is also known
to modulate the development or progression of several different diseases. The design of …

Drug transporters play an important role in the maintenance of chemical balance and
homeostasis in different tissues. In addition to their physiological functions, they are crucial …

A balanced communication between the mother, placenta and foetus is crucial to reach a
successful pregnancy. Several windows of exposure to environmental toxins are present …

Gestational diabetes mellitus (GDM) characterizes by foetoplacental endothelial dysfunction.
Human umbilical vein endothelial cells (HUVECs) from women with GDM show increased L …

The endothelium, which constitutes the inner layer of blood vessels and lymphatic
structures, plays an important role in various physiological functions. Alterations in structure …