[HTML][HTML] A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage
C Lou, JL Goodier, R Qiang - Reproductive Biology and Endocrinology, 2020 - Springer
LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new
sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions …
sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions …
Engineered LINE-1 retrotransposition in nondividing human neurons
Half the human genome is made of transposable elements (TEs), whose ongoing activity
continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon …
continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon …
[HTML][HTML] MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells
JL Goodier, LE Cheung, HH Kazazian Jr - 2012 - journals.plos.org
MOV10 protein, a putative RNA helicase and component of the RNA–induced silencing
complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts …
complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts …
[HTML][HTML] The impact of transposable element activity on therapeutically relevant human stem cells
GG Schumann, NV Fuchs, P Tristán-Ramos, A Sebe… - Mobile DNA, 2019 - Springer
Human stem cells harbor significant potential for basic and clinical translational research as
well as regenerative medicine. Currently~ 3000 adult and~ 30 pluripotent stem cell-based …
well as regenerative medicine. Currently~ 3000 adult and~ 30 pluripotent stem cell-based …
[HTML][HTML] Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
GC Pereira, L Sanchez, PM Schaughency… - Mobile Dna, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
[HTML][HTML] Transcriptional profiling of HERV-K (HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins
J Mayer, C Harz, L Sanchez, GC Pereira… - Molecular …, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. About
90% of ALS cases are without a known genetic cause. The human endogenous retrovirus …
90% of ALS cases are without a known genetic cause. The human endogenous retrovirus …
[HTML][HTML] PIWI-interacting RNA (piRNA) signatures in human cardiac progenitor cells
S Vella, A Gallo, AL Nigro, D Galvagno… - The international journal …, 2016 - Elsevier
Cardiac progenitors, such as cardiospheres and cardiosphere-derived cells, represent an
attractive cell source for cardiac regeneration. The PIWI-interacting RNAs, piRNAs, are an …
attractive cell source for cardiac regeneration. The PIWI-interacting RNAs, piRNAs, are an …
Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells
Hydroquinone (HQ) is an important benzene-derived metabolite associated with acute
myelogenous leukemia risk. Although altered DNA methylation has been reported in both …
myelogenous leukemia risk. Although altered DNA methylation has been reported in both …
LINE-1 retrotransposon encoded ORF1p expression and promoter methylation in oral squamous cell carcinoma: a pilot study
S Budania, D Sur, J Nangal, S Pilli, K Mukherjee… - Cancer Genetics, 2020 - Elsevier
Oral squamous cell carcinoma (OSCC) is highly predominant in India due to excessive use
of tobacco. Here we investigated Long INterpersed Element 1 (LINE or L1) retrotransposon …
of tobacco. Here we investigated Long INterpersed Element 1 (LINE or L1) retrotransposon …
Study of transposable elements and their genomic impact
M Muñoz-Lopez, R Vilar-Astasio… - … : Methods and Protocols, 2016 - Springer
Transposable elements (TEs) have been considered traditionally as junk DNA, ie, DNA
sequences that despite representing a high proportion of genomes had no evident cellular …
sequences that despite representing a high proportion of genomes had no evident cellular …