Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Heart failure (HF) involves changes in cardiac structure, myocardial composition, myocyte
deformation, and multiple biochemical and molecular alterations that impact heart function …

Background—Biomarkers that predict response to cardiac resynchronization therapy (CRT)
in heart failure patients with dyssynchrony (HFDYS) would be clinically important …

Objectives: We sought to investigate the impact of left ventricular (LV) pacing site on
mechanical response to cardiac resynchronization therapy (CRT) in patients with ischemic …

Cardiac resynchronization therapy (CRT) is an accepted treatment for patients with heart
failure (HF), impaired left ventricular (LV) function, and a wide QRS complex. It has been …

CRT partially restores DHF-induced electrophysiological remodeling, abnormal Ca
homeostasis, blunted β-adrenergic responsiveness, and regional heterogeneity of APD, and …

The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms
to tightly couple fuel supply with energy demand across a wide range of physiologic and …

Rationale: Cardiac resynchronization therapy (CRT) is an established treatment for patients
with chronic heart failure. However, CRT-associated structural and functional remodeling at …

Background—Cardiac resynchronization therapy (CRT) improves chamber
mechanoenergetics and morbidity and mortality of patients manifesting heart failure with …

Mitochondrial abnormalities have long been described in the setting of cardiomyopathies
and heart failure (HF), yet the mechanisms of mitochondrial dysfunction in cardiac …