Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular
matrix is excessively deposited. Fibrosis can lead to vital organ failure and there are no …

Dosimetry modeling and point of departure (POD) estimation using in vitro data are essential
for mechanism-based hazard identification and risk assessment. This study aimed to …

Prolonged exposure to environmental respirable toxicants can lead to the development and
worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary …

Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to
cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to …

Epithelial-mesenchymal transition (EMT) is a complex reversible biological process
characterized by the loss of epithelial features and the acquisition of mesenchymal features …

Silica dust is a common pollutant in the occupational environment, such as coal mines.
Inhalation of silica dust can cause progressive pulmonary fibrosis and then silicosis …

Extracellular vesicles (EVs) play novel roles in homeostasis through cell-to-cell
communication in human airways via transferring miRNAs. However, the contribution of EV …

Background Lung injury elicited by respiratory exposure to humidifier disinfectants (HDs) is
known as HD-associated lung injury (HDLI). Current elucidation of the molecular …

The expression of GPR50 in CSLC and several breast cancer cell lines was assessed by RT-
PCR and online platform (UALCAN, GEPIA, and R2 gene analysis). The role of GPR50 in …

Emodin is a natural anthraquinone compound, which is the main component found in the
traditional Chinese herb Polygonum cuspidatum. The anti‐fibrosis effects of Emodin have …