Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

When the VEGF-A-targeting monoclonal antibody bevacizumab (Avastin®) entered clinical
practice more than 15 years ago, it was one of the first targeted therapies and the first …

The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-
deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its …

Purpose: Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into
Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter being strongly …

A majority of cancers are driven by genomic alterations that dysregulate key oncogenic
pathways influencing cell growth and survival. However, the ability to harness tumor genetic …

Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …

Enhancer of zeste homolog (EZH2) is a key epigenetic regulator of gene expression and is
frequently overexpressed in various cancer types, suggesting a role in oncogenesis. The …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …

Abstract Enhancer of Zeste Homolog 2 (EZH2), a key epigenetic regulator, is involved in
breast cancer progression and metastasis. LOXL4 is increasingly recognized as an …

Colon cancer is one of the most frequently diagnosed cancer and the third most fatal
malignancy worldwide. HOTAIR, a cancer-associated long non-coding RNA (lncRNA), is a …