Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …

Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …

The balance between cell death and survival is a critical parameter in the regulation of cells
and the maintenance of homeostasis in vivo. Three major mechanisms for cell death have …

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …

Emerging evidence suggests that the clinical success of conventional chemotherapy is not
solely attributed to tumor cell toxicity, but also results from the restoration of …

Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that
resemble those associated with aging, and normal and pathological aging are often …

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell
death. The removal of damaged mitochondria through autophagy, a process called …

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …

The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …