Pathophysiology of TMD pain–basic mechanisms and their implications for pharmacotherapy

BE Cairns - Journal of oral rehabilitation, 2010 - Wiley Online Library
This article discusses the pathophysiology of temporomandibular disorders (TMD)‐related
pain and its treatment with analgesic drugs. Temporomandibular disorders are comprised of …

Peripheral and central mechanisms of orofacial inflammatory pain

BJ Sessle - International review of neurobiology, 2011 - Elsevier
Many orofacial pain conditions involve inflammation of orofacial tissues and they range from
acute pulpitis (toothache) and mucositis to chronic arthritic conditions affecting the …

TMD in females with menstrual disorders

B Jedynak, M Jaworska-Zaremba… - International journal of …, 2021 - mdpi.com
Background: Temporomandibular disorders (TMD) are a common reason for patients to
present at dental offices. The majority of people with TMD are women between the age of 20 …

Sex as a biological variable in oral diseases: evidence and future prospects

L Sangalli, LC Souza, A Letra… - Journal of Dental …, 2023 - journals.sagepub.com
The interest of the scientific community on sex and gender differences in health and disease
has increased substantially over the past 25 to 30 y as a result of a long process of events …

Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study.

C Hirsch, J Hoffmann, JC Türp - Journal of Orofacial …, 2012 - search.ebscohost.com
Background. In addition to low back pain, temporomandibular disorders (TMDs) are the most
prevalent pain-and disability-related musculoskeletal conditions. However, the influence of …

Sex‐related differences in animal models of migraine headache

H Bolay, NEJ Berman, D Akcali - … The Journal of Head and Face …, 2011 - Wiley Online Library
(Headache 2011; 51: 891‐904) Trigeminal nerve‐mediated pain disorders such as
migraine, temporomandibular joint disorder, and classical trigeminal neuralgia are more …

Effect of gonadal steroid hormones on formalin‐induced temporomandibular joint inflammation

KE Torres‐Chávez, JM Sanfins… - … Journal of Pain, 2012 - Wiley Online Library
We have recently demonstrated that gonadal steroid hormones decrease formalin‐induced
temporomandibular joint nociception in rats. Given that the attenuation of inflammation is a …

Estrogen in cycling rats alters gene expression in the temporomandibular joint, trigeminal ganglia and trigeminal subnucleus caudalis/upper cervical cord junction

J Puri, LL Bellinger, PR Kramer - Journal of cellular physiology, 2011 - Wiley Online Library
Females report temporomandibular joint (TMJ) pain more than men and studies suggest
estrogen modulates this pain response. Our goal in this study was to determine genes that …

Activational action of testosterone on androgen receptors protects males preventing temporomandibular joint pain

LE Fanton, CG Macedo, KE Torres-Chávez… - Pharmacology …, 2017 - Elsevier
Background Testosterone protects male rats from Temporomandibular Joint (TMJ) pain. This
study investigated whether this protective effect is mediated by an organizational action of …

Coactivation of µ-and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male …

CG Macedo, LE Fanton, L Fischer… - Journal of Oral & …, 2016 - search.ebscohost.com
Aims: To investigate whether the protective effect of testosterone on the development of
temporomandibular joint (TMJ) nociception in male rats is mediated by the activation of …