The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Heme is essential for the survival of virtually all living systems─ from bacteria, fungi, and
yeast, through plants to animals. No eukaryote has been identified that can survive without …

The heme molecule serves as an essential prosthetic group for oxygen transport and
storage proteins, as well for cellular metabolic enzyme activities, including those involved in …

Heme oxygenase-1 (HO-1) is an enzyme located at the endoplasmic reticulum, which is
responsible for the degradation of cellular heme into ferrous iron, carbon monoxide and …

Heme oxygenase-2 (HO2) and-1 (HO1) catalyze heme degradation to biliverdin, CO, and
iron, forming an essential link in the heme metabolism network. Tight regulation of the …

Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing
equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in …

Heme is an essential biomolecule and cofactor involved in a myriad of biological processes.
In this review, we focus on how heme binding to heme regulatory motifs (HRMs), catalytic …

Heme oxygenases (HOs) detoxify heme by oxidatively degrading it into carbon monoxide,
iron, and biliverdin, which is reduced to bilirubin and excreted. Humans express two …

Cadmium (Cd) is a pervasive toxic metal, present in most food types, cigarette smoke, and
air. Most cells in the body will assimilate Cd, as its charge and ionic radius are similar to the …

Heme is an iron-containing prosthetic group necessary for the function of several proteins
termed" hemoproteins." Erythrocytes contain most of the body's heme in the form of …