Role of sleep deprivation in immune-related disease risk and outcomes

S Garbarino, P Lanteri, NL Bragazzi… - Communications …, 2021 - nature.com
Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

The sleep-immune crosstalk in health and disease

L Besedovsky, T Lange, M Haack - Physiological reviews, 2019 - journals.physiology.org
Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

Sleep and inflammation: partners in sickness and in health

MR Irwin - Nature Reviews Immunology, 2019 - nature.com
The discovery of reciprocal connections between the central nervous system, sleep and the
immune system has shown that sleep enhances immune defences and that afferent signals …

Sleep health: reciprocal regulation of sleep and innate immunity

MR Irwin, MR Opp - Neuropsychopharmacology, 2017 - nature.com
Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …

Evidence for an immune response in major depression: a review and hypothesis

M Maes - Progress in Neuro-Psychopharmacology and …, 1995 - Elsevier
1. This paper reviews recent findings on cellular and humoral immunity and inflammatory
markers in depression. 2. 2. It is shown that major depression may be accompanied by …

The bidirectional relationship between sleep and immunity against infections

EG Ibarra-Coronado… - Journal of …, 2015 - Wiley Online Library
Sleep is considered an important modulator of the immune response. Thus, a lack of sleep
can weaken immunity, increasing organism susceptibility to infection. For instance, shorter …

How (and why) the immune system makes us sleep

L Imeri, MR Opp - Nature Reviews Neuroscience, 2009 - nature.com
Good sleep is necessary for physical and mental health. For example, sleep loss impairs
immune function, and sleep is altered during infection. Immune signalling molecules are …

Role of interleukin‐6 in stress, sleep, and fatigue

N Rohleder, M Aringer… - Annals of the New York …, 2012 - Wiley Online Library
Chronic low‐grade inflammation, in particular increased concentrations of proinflammatory
cytokines such as interleukin (IL)‐6 in the circulation, is observed with increasing age, but it …

Effects of sleep and sleep loss on immunity and cytokines

M Irwin - Brain, behavior, and immunity, 2002 - Elsevier
Sleep is hypothesized to be a restorative process that is important for the proper functioning
of the immune system. Severity of disordered sleep in depressed-and alcoholic subjects …

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

M Maes, S Scharpé, HY Meltzer, E Bosmans, E Suy… - Psychiatry …, 1993 - Elsevier
Recent studies from this laboratory have provided some evidence that major depression, in
particular melancholia, may be accompanied by an immune response. The present study …