Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …

Reduced nitrogen is an essential component of nucleic acids and proteins, and thus, all
organisms require this nutrient for growth. Unfortunately, even though elemental dinitrogen …

The three-dimensional structure of the complex between human H-Ras bound to guanosine
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …

Dynamins are large GTPases that belong to a protein superfamily that, in eukaryotic cells,
includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and …

Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

This review is concerned with the structures and mechanisms of a superfamily of regulatory
GTP hydrolases (G proteins). G proteins include Ras and its close homologs, translation …

The crystal structure of a soluble, catalytically active form of adenylyl cyclase in a complex
with its stimulatory heterotrimeric G protein α subunit (Gs α) and forskolin was determined to …

The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases,, which
act as molecular switches in diverse signal-transduction processes. Various bacterial toxins …

The sequential addition of amino acids to a growing polypeptide chain is carried out by the
ribosome in a complicated multistep process called the elongation cycle. It involves accurate …

Ras proteins are small GTPases, cycling between inactive GDP-bound and active GTP-
bound states. Through these switches they regulate signaling that controls cell growth and …