Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
ER morphology in the pathogenesis of hereditary spastic paraplegia
The endoplasmic reticulum (ER) is the most abundant and widespread organelle in cells. Its
peculiar membrane architecture, formed by an intricate network of tubules and cisternae, is …
peculiar membrane architecture, formed by an intricate network of tubules and cisternae, is …
[HTML][HTML] Verification of pain-related neuromodulation mechanisms of icariin in knee osteoarthritis
Knee osteoarthritis (KOA) is a common disease with no specific treatment. Icariin (ICA) is
considered an agent for KOA. This study aimed to confirm the pain-related neuromodulation …
considered an agent for KOA. This study aimed to confirm the pain-related neuromodulation …
The nanoscale organization of reticulon 4 shapes local endoplasmic reticulum structure in situ
LA Fuentes, Z Marin, J Tyson, D Baddeley… - Journal of Cell …, 2023 - rupress.org
The endoplasmic reticulum's (ER's) structure is directly linked to the many functions of the
ER, but its formation is not fully understood. We investigate how the ER–membrane curving …
ER, but its formation is not fully understood. We investigate how the ER–membrane curving …
Identification of candidate genes associated with clinical onset of Alzheimer's disease
W Liao, H Luo, Y Ruan, Y Mai, C Liu, J Chen… - Frontiers in …, 2022 - frontiersin.org
Background and objective Alzheimer's disease (AD) is the most common type of dementia,
with its pathology like beta-amyloid and phosphorylated tau beginning several years before …
with its pathology like beta-amyloid and phosphorylated tau beginning several years before …
Unveiling the modulation of Nogo receptor in neuroregeneration and plasticity: novel aspects and future horizon in a new frontier
Neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, Multiple Sclerosis,
Hereditary Spastic Paraplegia, and Amyotrophic Lateral Sclerosis have emerged as the …
Hereditary Spastic Paraplegia, and Amyotrophic Lateral Sclerosis have emerged as the …
O-GlcNAcylation enhances Reticulon 2 protein stability and its promotive effects on gastric cancer progression
G Wang, Z Xu, J Sun, B Liu, Y Ruan, J Gu, S Song - Cellular Signalling, 2023 - Elsevier
Our previous study indicated that Reticulon 2 (RTN2) was upregulated and facilitated the
progression of gastric cancer. Protein O-linked β-N-acetylglucosaminylation (O …
progression of gastric cancer. Protein O-linked β-N-acetylglucosaminylation (O …
[PDF][PDF] Amyotrophic lateral sclerosis with primary progressive aphasia: A case report and literature review
A Zhang, H Xu, J Huang, S Guo, T Tian, X Lei… - Neuroendocrinology …, 2022 - nel.edu
The association between amyotrophic lateral sclerosis (ALS) and primary progressive
aphasia (PPA) is rarely seen in patients. A case of ALS-PPA with a possible reticulon 2 …
aphasia (PPA) is rarely seen in patients. A case of ALS-PPA with a possible reticulon 2 …