Immune Checkpoint Inhibitor Therapy in Oncology: Current Uses and Future Directions: JACC: CardioOncology State-of-the-Art Review
S Tan, D Day, SJ Nicholls, E Segelov - Cardio Oncology, 2022 - jacc.org
Immune checkpoint inhibitors (ICIs) are a major class of immuno-oncology therapeutics that
have significantly improved the prognosis of various cancers, both in (neo) adjuvant and …
have significantly improved the prognosis of various cancers, both in (neo) adjuvant and …
Molecular tumour boards—current and future considerations for precision oncology
AM Tsimberidou, M Kahle, HH Vo, MA Baysal… - Nature Reviews …, 2023 - nature.com
Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …
especially regarding the use of matched targeted therapies against specific oncogenic …
Pembrolizumab plus chemotherapy in advanced endometrial cancer
RN Eskander, MW Sill, L Beffa, RG Moore… - … England Journal of …, 2023 - Mass Medical Soc
Background Standard first-line chemotherapy for endometrial cancer is paclitaxel plus
carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear …
carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear …
Uterine neoplasms, version 1.2023, NCCN clinical practice guidelines in oncology
Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly
as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the …
as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the …
[HTML][HTML] Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy
L Cao, H Tian, M Fang, Z Xu, D Tang, J Chen, J Yin… - Biomaterials, 2022 - Elsevier
Abstract cGAS-STING pathway, as an essential intracellular immune response pathway, has
attracted much attention in tumor immunotherapy. However, low metabolic stability of …
attracted much attention in tumor immunotherapy. However, low metabolic stability of …
Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors
Immune-checkpoint inhibitors show promising effects in the treatment of multiple tumor
types. Biomarkers are biological indicators used to select patients for a systemic anticancer …
types. Biomarkers are biological indicators used to select patients for a systemic anticancer …
Hot and cold tumors: Immunological features and the therapeutic strategies
L Wang, H Geng, Y Liu, L Liu, Y Chen, F Wu, Z Liu… - MedComm, 2023 - Wiley Online Library
Abstract The “hotness” or “coldness” of the tumors are determined by the information of the
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …
Role of genomic and molecular biology in the modulation of the treatment of endometrial cancer: narrative review and perspectives
I Cuccu, O D'Oria, L Sgamba, E De Angelis… - Healthcare, 2023 - mdpi.com
Endometrial cancer (EC) is one of the most common gynecological malignancies in Western
countries. Traditionally, loco-reginal dissemination and histological characteristics are the …
countries. Traditionally, loco-reginal dissemination and histological characteristics are the …
Agnostic approvals in oncology: getting the right drug to the right patient with the right genomics
V Tateo, PV Marchese, V Mollica, F Massari… - Pharmaceuticals, 2023 - mdpi.com
(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …
medicine, led by the discovery of druggable genes or immune targets assessed through next …
Microsatellite instability: from the implementation of the detection to a prognostic and predictive role in cancers
M Amato, R Franco, G Facchini, R Addeo… - International journal of …, 2022 - mdpi.com
Microsatellite instability (MSI) has been identified in several tumors arising from either
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …