HLA Class Ib-receptor interactions during embryo implantation and early pregnancy

LL Nilsson, TVF Hviid - Human Reproduction Update, 2022 - academic.oup.com
BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

XW Wei, YC Zhang, F Wu, FJ Tian, Y Lin - Frontiers in Immunology, 2022 - frontiersin.org
Successful embryo implantation requires both a receptive endometrium and competent
blastocysts. After implantation, the maternal decidua undergoes a series of changes …

A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion

SG Zambuto, KBH Clancy, BAC Harley - Interface Focus, 2019 - royalsocietypublishing.org
The endometrium is the lining of the uterus and site of blastocyst implantation. Each
menstrual cycle, the endometrium cycles through rapid phases of growth, remodelling and …

Endometrial HLA-F expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients

H Papúchová, MH Saxtorph, T Hallager… - Human …, 2022 - academic.oup.com
STUDY QUESTION Is human leukocyte antigen (HLA)-F protein expressed in mid-secretory
endometrium, and are its expression levels influenced by HLA-F gene polymorphisms and …

A role for both HLA-F and HLA-G in reproduction and during pregnancy?

G Persson, N Jørgensen, LL Nilsson, LHJ Andersen… - Human immunology, 2020 - Elsevier
The human major histocompatibility complex includes a group of non-classical HLA class I
genes, HLA-E,-F and-G. While nearly all focus since the discovery of these class Ib …

Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia

F Luo, F Liu, Y Guo, W Xu, Y Li, J Yi, T Fournier… - Frontiers in …, 2023 - frontiersin.org
Background Preeclampsia is a pregnancy-specific disorder that always causes maternal
and fetal serious adverse outcome. Disturbances in maternal immune tolerance to embryo at …

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

NJ Sakabe, I Aneas, N Knoblauch, DR Sobreira… - Science …, 2020 - science.org
While a genetic component of preterm birth (PTB) has long been recognized and recently
mapped by genome-wide association studies (GWASs), the molecular determinants …

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

YK Bozhilov, DJ Downes, J Telenius… - Nature …, 2021 - nature.com
Many single nucleotide variants (SNVs) associated with human traits and genetic diseases
are thought to alter the activity of existing regulatory elements. Some SNVs may also create …

Are different markers of endometrial receptivity telling us different things about endometrial function?

M Hviid Saxtorph, G Persson, T Hallager… - American Journal of …, 2020 - Wiley Online Library
Problem To what extent do endocrine, immunological, gene expression and histological
markers of endometrial receptivity correlate? Method of study Between November 2017 and …

[HTML][HTML] Narrative review of the relationship between the maternal-fetal interface immune tolerance and the onset of preeclampsia

F Luo, J Yue, L Li, J Mei, X Liu… - Annals of translational …, 2022 - ncbi.nlm.nih.gov
Narrative review of the relationship between the maternal-fetal interface immune tolerance and
the onset of preeclampsia - PMC Back to Top Skip to main content NIH NLM Logo Access keys …