Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Neurogenesis is an important process in the regulation of brain function and behaviour,
highly active in early development and continuing throughout life. Recent studies have …

Activation of Notch signaling induces the expression of transcriptional repressor genes such
as Hes1, leading to repression of proneural gene expression and maintenance of neural …

The procedure of neurogenesis has made numerous achievements in the past decades,
during which various molecular biomarkers have been emerging and have been broadly …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

The potential to increase unlimitedly in number and to generate differentiated cell types is a
key feature of somatic stem cells. Within the nervous system, cellular and environmental …

Recent clinical data have implicated chronic adverse stress as a potential risk factor in the
development of Alzheimer's disease (AD) and data also suggest that normal, physiological …

It is long known that stem cell differentiation correlates with a lengthening of the cell cycle, in
particular G1. Moreover, models were proposed for mammalian embryonic, neural and …

Cumulative evidence has indicated that there is an important role for adult hippocampal
neurogenesis in cognitive function. With the increasing prevalence of cognitive decline …

Some 40 years ago it was recognized by Furchgott and colleagues that the endothelium
releases a vasodilator, endothelium-derived relaxing factor (EDRF). Later on, several …