Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …

Objectives To identify a novel plasmid-mediated colistin resistance gene in Klebsiella
pneumoniae isolated from chickens in China. Methods WGS was used to identify a novel …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Transposable elements (TE), small mobile genetic elements unable to exist independently
of the host genome, were initially believed to be exclusively deleterious genomic parasites …

Objectives To determine the occurrence of mcr-1 and mcr-2 genes in Gram-negative
bacteria isolated from healthy pigs in Great Britain. Methods Gram-negative bacteria (n …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …