CRAC channels and calcium signaling in T cell-mediated immunity
Calcium (Ca 2+) signals play fundamental roles in immune cell function. The main sources
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …
of Ca 2+ influx in mammalian lymphocytes following antigen receptor stimulation are Ca 2+ …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease
A Michelucci, M García-Castañeda, S Boncompagni… - Cell calcium, 2018 - Elsevier
Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …
ORAI1 mutations abolishing store-operated Ca2+ entry cause anhidrotic ectodermal dysplasia with immunodeficiency
Background Store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+
channels is an essential signaling pathway in many cell types. Ca 2+ release–activated Ca …
channels is an essential signaling pathway in many cell types. Ca 2+ release–activated Ca …
STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases
Store-operated Ca2+ entry (SOCE) is a ubiquitous and essential mechanism regulating
Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including …
Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including …
Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
AR Concepcion, M Vaeth, LE Wagner… - The Journal of …, 2016 - Am Soc Clin Investig
Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-
function mutations in the Ca2+ release–activated Ca2+ (CRAC) channel genes ORAI1 and …
function mutations in the Ca2+ release–activated Ca2+ (CRAC) channel genes ORAI1 and …
ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling
H Shawer, K Norman, CW Cheng, R Foster… - Frontiers in Cell and …, 2021 - frontiersin.org
In the adult, vascular smooth muscle cells (VSMC) are normally physiologically quiescent,
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …
arranged circumferentially in one or more layers within blood vessel walls. Remodelling of …
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells
S Kahlfuss, U Kaufmann, AR Concepcion… - EMBO molecular …, 2020 - embopress.org
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system
including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction …
including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction …
STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice
R Silva-Rojas, S Treves, H Jacobs… - Human molecular …, 2019 - academic.oup.com
Strict regulation of Ca2+ homeostasis is essential for normal cellular physiology. Store-
operated Ca2+ entry (SOCE) is a major mechanism controlling basal Ca2+ levels and …
operated Ca2+ entry (SOCE) is a major mechanism controlling basal Ca2+ levels and …
Store-Operated Ca2+ Entry Is Up-Regulated in Tumour-Infiltrating Lymphocytes from Metastatic Colorectal Cancer Patients
Simple Summary Store-operated Ca2+ entry (SOCE) has long been known to regulate the
differentiation and effector functions of T cells as well as to be instrumental to the ability of …
differentiation and effector functions of T cells as well as to be instrumental to the ability of …