Role of neuroinflammation in neurodegeneration development

W Zhang, D Xiao, Q Mao, H Xia - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

[HTML][HTML] The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

C Grinán-Ferré, A Bellver-Sanchis, V Izquierdo… - Ageing Research …, 2021 - Elsevier
While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Inflammation context in Alzheimer's disease, a relationship intricate to define

C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Systematic review of miRNA as biomarkers in Alzheimer's disease

S Swarbrick, N Wragg, S Ghosh, A Stolzing - Molecular neurobiology, 2019 - Springer
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …

ApoE4: an emerging therapeutic target for Alzheimer's disease

M Safieh, AD Korczyn, DM Michaelson - BMC medicine, 2019 - Springer
Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Epigenetics of Alzheimer's disease

M Nikolac Perkovic, A Videtic Paska, M Konjevod… - Biomolecules, 2021 - mdpi.com
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Deficiency in the ubiquitin conjugating enzyme UBE2A in Alzheimer's disease (AD) is linked to deficits in a natural circular miRNA-7 sponge (circRNA; ciRS-7)

Y Zhao, PN Alexandrov, V Jaber, WJ Lukiw - Genes, 2016 - mdpi.com
Our understanding of the highly specialized functions for small non-coding single-stranded
RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

MicroRNAs in neuroinflammation: implications in disease pathogenesis, biomarker discovery and therapeutic applications

JA Slota, SA Booth - Non-coding RNA, 2019 - mdpi.com
The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …

MicroRNA-146a: a dominant, negative regulator of the innate immune response

R Saba, DL Sorensen, SA Booth - Frontiers in immunology, 2014 - frontiersin.org
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that can play critical
roles as regulators of numerous pathways and biological processes including the immune …