Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

Transition metals and virulence in bacteria

LD Palmer, EP Skaar - Annual review of genetics, 2016 - annualreviews.org
Transition metals are required trace elements for all forms of life. Due to their unique
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …

The role of copper and zinc toxicity in innate immune defense against bacterial pathogens

KY Djoko, YO Cheryl-lynn, MJ Walker… - Journal of Biological …, 2015 - ASBMB
Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …

[HTML][HTML] Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate

SA Ledari, JM Milani, SA Shahidi, A Golkar - Food Chemistry: X, 2024 - Elsevier
Chlorophyll (Chl) is a healthy green pigment that is very unstable. So, chlorophyll
microcapsules were fabricated using maltodextrin and whey protein isolate as carriers and …

Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface

DA Capdevila, J Wang, DP Giedroc - Journal of Biological Chemistry, 2016 - ASBMB
Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …

Metals as phagocyte antimicrobial effectors

JR Sheldon, EP Skaar - Current Opinion in Immunology, 2019 - Elsevier
Highlights•Iron and manganese are withheld from the phagosome to inhibit bacterial
growth.•Excess copper and zinc are used to directly intoxicate intracellular …

Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections

Z Su, D Xu, X Hu, W Zhu, L Kong, Z Qian, J Mei… - Nature …, 2024 - nature.com
Pathogen-host competition for manganese and intricate immunostimulatory pathways
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …

Role of calprotectin in withholding zinc and copper from Candida albicans

AN Besold, BA Gilston, JN Radin… - Infection and …, 2018 - Am Soc Microbiol
The opportunistic fungal pathogen Candida albicans acquires essential metals from the
host, yet the host can sequester these micronutrients through a process known as nutritional …

Bacterial zinc uptake regulator proteins and their regulons

A Mikhaylina, AZ Ksibe, DJ Scanlan… - Biochemical Society …, 2018 - portlandpress.com
All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …