Metals to combat antimicrobial resistance
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
Nutritional immunity: the battle for nutrient metals at the host–pathogen interface
CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …
Transition metals and virulence in bacteria
Transition metals are required trace elements for all forms of life. Due to their unique
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …
inorganic and redox properties, transition metals serve as cofactors for enzymes and other …
The role of copper and zinc toxicity in innate immune defense against bacterial pathogens
Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …
[HTML][HTML] Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate
Chlorophyll (Chl) is a healthy green pigment that is very unstable. So, chlorophyll
microcapsules were fabricated using maltodextrin and whey protein isolate as carriers and …
microcapsules were fabricated using maltodextrin and whey protein isolate as carriers and …
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface
DA Capdevila, J Wang, DP Giedroc - Journal of Biological Chemistry, 2016 - ASBMB
Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …
Metals as phagocyte antimicrobial effectors
JR Sheldon, EP Skaar - Current Opinion in Immunology, 2019 - Elsevier
Highlights•Iron and manganese are withheld from the phagosome to inhibit bacterial
growth.•Excess copper and zinc are used to directly intoxicate intracellular …
growth.•Excess copper and zinc are used to directly intoxicate intracellular …
Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections
Pathogen-host competition for manganese and intricate immunostimulatory pathways
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …
Role of calprotectin in withholding zinc and copper from Candida albicans
AN Besold, BA Gilston, JN Radin… - Infection and …, 2018 - Am Soc Microbiol
The opportunistic fungal pathogen Candida albicans acquires essential metals from the
host, yet the host can sequester these micronutrients through a process known as nutritional …
host, yet the host can sequester these micronutrients through a process known as nutritional …
Bacterial zinc uptake regulator proteins and their regulons
A Mikhaylina, AZ Ksibe, DJ Scanlan… - Biochemical Society …, 2018 - portlandpress.com
All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …