Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Ground squirrels–experts in thermoregulatory adaptation

VV Feketa, SN Bagriantsev, EO Gracheva - Trends in Neurosciences, 2023 - cell.com
Ground squirrels exemplify one of the most extreme forms of mammalian hibernation and a
convenient model for studying its mechanisms. Their thermoregulatory system demonstrates …

Liver transcriptome dynamics during hibernation are shaped by a shifting balance between transcription and RNA stability

AE Gillen, R Fu, KA Riemondy, J Jager, B Fang… - Frontiers in …, 2021 - frontiersin.org
Hibernators dramatically lower metabolism to save energy while fasting for months.
Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge …

Comparative transcriptomics of the garden dormouse hypothalamus during hibernation

E Haugg, J Borner, G Stalder, A Kübber‐Heiss… - FEBS Open …, 2024 - Wiley Online Library
Torpor or heterothermy is an energy‐saving mechanism used by endotherms to overcome
harsh environmental conditions. During winter, the garden dormouse (Eliomys quercinus) …

Comparative transcriptomics of the Djungarian hamster hypothalamus during short photoperiod acclimation and spontaneous torpor

E Haugg, J Borner, V Diedrich, A Herwig - FEBS Open Bio, 2022 - Wiley Online Library
The energy‐saving strategy of Djungarian hamsters (Phodopus sungorus, Cricetidae) to
overcome harsh environmental conditions comprises of behavioral, morphological, and …

Blood transcriptomics mirror regulatory mechanisms during hibernation—a comparative analysis of the Djungarian hamster with other mammalian species

VR Cuyutupa, D Moser, V Diedrich, Y Cheng… - … -European Journal of …, 2023 - Springer
Hibernation enables many species of the mammalian kingdom to overcome periods of harsh
environmental conditions. During this physically inactive state metabolic rate and body …

Adrenal gene expression dynamics support hibernation in 13-lined ground squirrels

AE Gillen, LE Epperson, DJ Orlicky… - Physiological …, 2023 - journals.physiology.org
Hibernation is a natural model of extreme physiology in a mammal. Throughout winter, small
hibernators repeatedly undergo rapid, dramatic swings in body temperature, perfusion, and …

Numerous independent gains of torpor and hibernation across endotherms, linked with adaptation to diverse environments

DG Kontopoulos, DL Levesque, M Hiller - bioRxiv, 2023 - biorxiv.org
Many endotherms from diverse taxonomic groups can respond to environmental changes
through dormancy, ie, by greatly reducing their energy expenditure for up to 24 hours (daily …

Ecology Meets Physiology: Phenotypic Plasticity and the Ability of Animals to Adjust to Changing Environmental Conditions

JP Hildebrandt - Physiologia, 2023 - mdpi.com
Hyperplasia and hypertrophy, or their counterparts hypoplasia and hypotrophy, are
elements of the adjustment of organ size and function in animals according to their needs …

Identification of conserved gene expression programs activated in multiple modes of torpor across vertebrate clades.

K Weir, N Vega, V Busa, B Sajdak, L Kallestad… - bioRxiv, 2023 - biorxiv.org
Torpor encompasses adaptations to diverse extreme environmental stressors such as
hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an …