Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis

M Margoni, P Preziosa, MA Rocca, M Filippi - Translational Psychiatry, 2023 - nature.com
Neuropsychiatric abnormalities may be broadly divided in two categories: disorders of
mood, affect, and behavior and abnormalities affecting cognition. Among these conditions …

Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant

MD Steenwijk, JJG Geurts, M Daams, BM Tijms… - Brain, 2016 - academic.oup.com
Abstract See Chard and Miller (doi: 10.1093/brain/awv354) for a scientific commentary on
this article. Grey matter atrophy is common in multiple sclerosis. However, in contrast with …

Cognitive impairment in multiple sclerosis–a review of current knowledge and recent research

T Grzegorski, J Losy - Reviews in the Neurosciences, 2017 - degruyter.com
Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is
characterised by inflammatory damage to the myelin sheath. Though often neglected …

Network collapse and cognitive impairment in multiple sclerosis

MM Schoonheim, KA Meijer, JJG Geurts - Frontiers in neurology, 2015 - frontiersin.org
The current field of multiple sclerosis (MS) research is an active and highly interesting one:
structural abnormalities such as inflammatory lesions and brain atrophy are studied with a …

[HTML][HTML] Task-and resting-state fMRI studies in multiple sclerosis: From regions to systems and time-varying analysis. Current status and future perspective

MA Rocca, MM Schoonheim, P Valsasina… - Neuroimage: Clinical, 2022 - Elsevier
Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …

[HTML][HTML] The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics

MM Schoonheim, TAA Broeders, JJG Geurts - NeuroImage: Clinical, 2022 - Elsevier
Multiple sclerosis is a neuroinflammatory and neurodegenerative disorder of the central
nervous system that can be considered a network disorder. In MS, lesional pathology …

Functional network connectivity abnormalities in multiple sclerosis: correlations with disability and cognitive impairment

MA Rocca, P Valsasina, VM Leavitt… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Objective: To investigate resting state (RS) functional connectivity (FC) abnormalities within
the principal brain networks in a large cohort of multiple sclerosis (MS) patients, to define the …

Increased default-mode network centrality in cognitively impaired multiple sclerosis patients

AJC Eijlers, KA Meijer, TM Wassenaar, MD Steenwijk… - Neurology, 2017 - AAN Enterprises
Objective: To investigate how changes in functional network hierarchy determine cognitive
impairment in multiple sclerosis (MS). Methods: A cohort consisting of 332 patients with MS …