The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …

Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …

An attractive approach to reduce gene expression is via the use of antisense
oligonucleotides (ASOs) that harness the RNase H1 mechanism. Here we show that RNase …