Pneumococcal surface proteins as virulence factors, immunogens, and conserved vaccine targets
Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
Streptococcus pneumoniae interactions with the complement system
E Gil, M Noursadeghi, JS Brown - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically
dependent on the complement system, demonstrated by the high incidence of invasive S …
dependent on the complement system, demonstrated by the high incidence of invasive S …
Recent progress in pneumococcal protein vaccines
S Li, H Liang, SH Zhao, XY Yang, Z Guo - Frontiers in Immunology, 2023 - frontiersin.org
Pneumococcal infections continue to pose a significant global health concern, necessitating
the development of effective vaccines. Despite the progress shown by pneumococcal …
the development of effective vaccines. Despite the progress shown by pneumococcal …
Diverse mechanisms of protective anti-pneumococcal antibodies
AD Gingerich, JJ Mousa - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The gram-positive bacterium Streptococcus pneumoniae is a leading cause of pneumonia,
otitis media, septicemia, and meningitis in children and adults. Current prevention and …
otitis media, septicemia, and meningitis in children and adults. Current prevention and …
A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia
TW Dos Santos, PA Gonçalves, D Rodriguez… - Plos one, 2022 - journals.plos.org
PspA and pneumolysin are two important vaccine candidates, able to elicit protection in
different models of pneumococcal infection. The high immunogenic potential of PspA …
different models of pneumococcal infection. The high immunogenic potential of PspA …
Prevalence and homology of the pneumococcal serine-rich repeat protein at the global scale
Pneumococcal pneumonia remains a WHO high-priority disease despite multivalent
conjugate vaccines administered in clinical practice worldwide. A protein-based, serotype …
conjugate vaccines administered in clinical practice worldwide. A protein-based, serotype …
Development of a bivalent protein-based vaccine candidate against invasive pneumococcal diseases based on novel pneumococcal surface protein A in combination …
E Afshari, R Ahangari Cohan… - Frontiers in …, 2023 - frontiersin.org
Extensive efforts have been made toward improving effective strategies for pneumococcal
vaccination, focusing on evaluating the potential of multivalent protein-based vaccines and …
vaccination, focusing on evaluating the potential of multivalent protein-based vaccines and …
Bioconjugation Vaccine Design Strategies Against Invasive Pneumococcal Disease
J Aceil - 2022 - search.proquest.com
Abstract To date, Streptococcus pneumoniae (Spn) remains a high-risk commensal that can
cause invasive pneumococcal diseases like pneumonia, otitis media, bacteremia and …
cause invasive pneumococcal diseases like pneumonia, otitis media, bacteremia and …
Identifying novel pneumococcal pneumonia vaccine candidates
K Cheliotis - 2022 - archive.lstmed.ac.uk
The burden of pneumococcal pneumonia remains high worldwide. The disease
disproportionately affects infants, the elderly and the immunocompromised. Nasopharyngeal …
disproportionately affects infants, the elderly and the immunocompromised. Nasopharyngeal …