Severe influenza infection represents a leading cause of global morbidity and mortality.
Although influenza is primarily considered a viral infection that results in pathology limited to …

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …

Cancer immunotherapy based on genetically redirecting T cells has been used successfully
to treat B cell malignancies,–. In this strategy, the T cell genome is modified by integration of …

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic
DNA into the host chromosomes, yet remarkably, the timing and cellular location of …

The success of adoptive T cell gene transfer for treatment of cancer and HIV is predicated on
generating a response that is both durable and safe. We report long-term results from three …

HIV-1 integration into the host genome favors actively transcribed genes. Prior work
indicated that the nuclear periphery provides the architectural basis for integration site …

Abstract Human immunodeficiency virus (HIV)-1 is able to replicate in primary human
macrophages without stimulating innate immunity despite reverse transcription of genomic …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC …

Integration is vital to retroviral replication and influences the establishment of the latent HIV
reservoir. HIV-1 integration favors active genes, which is in part determined by the …