Our understanding of the movement of water through cell membranes has been greatly
advanced by the discovery of a family of water-specific, membrane-channel proteins—the …

Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in
all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ …

Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma
membrane. Channel closure results either from the dephosphorylation of two conserved …

The study of water transport began long before the molecular identification of water
channels with studies of water-permeable tissues. The discovery of the first aquaporin …

Urea is an endogenous metabolite, known to enhance stratum corneum hydration. Yet,
topical urea anecdotally also improves permeability barrier function, and it appears to exhibit …

The flow of water and some other small molecules across cell membranes is important in
many of the processes underlying reproduction. The fluid movement is strongly associated …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous
mechanism within cell biology. This family of integral membrane proteins includes both …

Background The aquaporins are a family of integral membrane proteins composed of two
subfamilies: the orthodox aquaporins, which transport only water, and the …