CYP24A1 is the cytochrome P450 component of the 25-hydroxyvitamin D3-24-hydroxylase
enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OH-D3) and 1, 25 …

Objective To review the inter‐relationships between calcium, phosphorus, parathyroid
hormone (PTH), parent and activated vitamin D metabolites (vitamin D, 25 (OH)‐vitamin D …

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative
stress has long been thought to play a role in triggering podocyte damage; however, the …

Recent studies implicate Wnt/β-catenin signaling in podocyte dysfunction. Because vitamin
D analogs can inhibit β-catenin in other tissues, we tested whether the vitamin D analog …

Local inflammation is thought to contribute to the progression of diabetic nephropathy. The
vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human diabetic …

Results Mean estimated GFR (eGFR) was 35 ml/min per 1.73 m 2. At enrollment, the
increase in intact FGF23 with decreasing eGFR was the earliest among changes in MBD …

Vitamin D is typically viewed as a key player in the regulation of calcium and phosphate
levels and the control of bone metabolism; however, growing evidence suggests that vitamin …

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular
processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the …

Vitamin D presents a plethora of different functions that go beyond its role in skeletal
homeostasis. It is an efficient endocrine regulator of the Renin–Angiotensin–Aldosterone …

Podocyte injury is the main cause of proteinuria in lupus nephritis (LN). Nestin, an important
cytoskeleton protein, is expressed stably in podocytes and is associated with podocyte …