Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …

High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Inflammation is a pivotal driver of atherosclerotic plaque progression and rupture and is a
target for identifying vulnerable plaques. However, challenges arise with the current in vivo …

Recent studies have indicated that high-density lipoproteins (HDLs) and their major
structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are …

Understanding the pathophysiology of atherogenesis and the progression of atherosclerosis
have been major goals of cardiovascular research during the previous decades. However …

Atherosclerosis is the main pathophysiological process underlying coronary artery disease
(CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by …

Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …

Rupture of a saccular intracranial artery aneurysm (IA) causes subarachnoid hemorrhage, a
significant cause of stroke and death. The current treatment options, endovascular coiling …