The role of genetic predisposition and the influence of sex steroid hormones are
indisputable to the pathogenesis of male androgenetic alopecia (MAGA). The role of sex …

The value of identifying women with an inherited predisposition to epithelial ovarian cancer
has become readily apparent with the identification of the BRCA1, and BRCA2 genes …

Context Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.
Objective To investigate the genetic regulation of serum E2 and E1 in men. Design, Setting …

Background Female pattern hair loss (FPHL) is a common trait in which androgens and
oestrogens may have a pathogenic role. The aromatase enzyme converts androgens to …

Breast cancer risk is strongly related to several reproductive and hormonal factors, but the
nature of the effects of endogenous oestrogens has been difficult to establish. Data are now …

Candidate gene studies have reported CYP19A1 variants to be associated with endometrial
cancer and with estradiol (E2) concentrations. We analyzed 2937 single nucleotide …

Aromatase inhibitors (AIs) are the first-line treatment in women with breast cancer for total
estrogen depletion. Half the treated women may develop pain, and this condition may …

Purpose: In estrogen receptor–positive (ER+) breast cancer, single-nucleotide
polymorphisms (SNP) in the aromatase gene might affect aromatase inhibitors (AI) …

Introduction Aromatase inhibitor-associated arthralgia (AIAA) is a common and often
debilitating symptom in breast cancer survivors. Since joint symptoms have been related to …

African-American (AA) women have earlier menarche on average than women of European
ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among …