Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

R Dong, KA Libby, F Blaeschke, W Fuchs… - The EMBO …, 2020 - embopress.org
The chimeric antigen receptor (CAR) directs T cells to target and kill specific cancer cells.
Despite the success of CAR T therapy in clinics, the intracellular signaling pathways that …

Imaging CAR-T synapse as a quality control for CAR engineering

Q Xiao, X Su - The Immune Synapse: Methods and Protocols, 2023 - Springer
The chimeric antigen receptor (CAR) evolves as a powerful tool to reprogram T cells for
targeted killing. CAR-T therapy succeeded in treating certain types of blood cancers, and its …

Identifying, Investigating, and Modulating Anti-CD19 CAR T Cells for Large B-Cell Lymphoma

Y Hu - 2022 - search.proquest.com
Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has improved treatment options
for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). During anti …