Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …

Human African trypanosomiasis (HAT), or sleeping sickness, is caused by Trypanosoma
brucei gambiense, which is a chronic form of the disease present in western and central …

Background Dinoflagellates are known for their capacity to form harmful blooms (eg," red
tides") and as symbiotic, photosynthetic partners for corals. These unicellular eukaryotes …

ABSTRACT TriTrypDB (http://tritrypdb. org) is an integrated database providing access to
genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex …

Horizontal gene transfer (HGT; also known as lateral gene transfer) has had an important
role in eukaryotic genome evolution, but its importance is often overshadowed by the greater …

Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that
affects 210 million people in 76 countries. Here we present analysis of the 363 megabase …

Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to
evade the immune responses of their hosts. These include antigenic variation, through …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Abstract Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the
African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and …