Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Major progress has been made in recent years in the development of Hedgehog (Hh)
pathway inhibitors for the treatment of patients with cancer. Promising clinical trial results …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Tumor relapse and metastasis remain major obstacles for improving overall cancer survival,
which may be due at least in part to the existence of cancer stem cells (CSCs). CSCs are …

The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human
cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

Abstract The Hedgehog (Hh) pathway has been implicated in a wide variety of human
tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a …

The conversion of chemical energy into mechanical force by AAA+ (ATPases associated
with diverse cellular activities) ATPases is integral to cellular processes, including DNA …

The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …