Mechanisms of protein search for targets on DNA: theoretical insights

AA Shvets, MP Kochugaeva, AB Kolomeisky - Molecules, 2018 - mdpi.com
Protein-DNA interactions are critical for the successful functioning of all natural systems. The
key role in these interactions is played by processes of protein search for specific sites on …

[HTML][HTML] Molecular search with conformational change: One-dimensional discrete-state stochastic model

J Shin, AB Kolomeisky - The Journal of chemical physics, 2018 - pubs.aip.org
Molecular search phenomena are observed in a variety of chemical and biological systems.
During the search, the participating particles frequently move in complex inhomogeneous …

Influence of oligonucleotide grafting density on Surface-Mediated DNA transport and hybridization

JC Traeger, Z Lamberty, DK Schwartz - ACS nano, 2019 - ACS Publications
Adsorption of soluble DNA to surfaces decorated with complementary DNA plays an
important role in many bionanotechnology applications, and previous studies have reported …

Facilitation of DNA loop formation by protein–DNA non-specific interactions

J Shin, AB Kolomeisky - Soft matter, 2019 - pubs.rsc.org
Complex DNA topological structures, including polymer loops, are frequently observed in
biological processes when protein molecules simultaneously bind to several distant sites on …

[HTML][HTML] The effect of obstacles in multi-site protein target search with DNA looping

C Felipe, J Shin, Y Loginova… - The Journal of Chemical …, 2020 - pubs.aip.org
Many fundamental biological processes are regulated by protein-DNA complexes called
synaptosomes, which possess multiple interaction sites. Despite the critical importance of …

Formation of α-helical and β-sheet Structures in Membrane-Bound Human IAPP Monomer and the Resulting Membrane Deformation

Q Qiao, G Wei, D Yao, Z Song - Physical Chemistry Chemical Physics, 2019 - pubs.rsc.org
The amyloid formation of human islet amyloid polypeptide (hIAPP)—an intrinsically
disordered peptide, is associated with type II diabetes. Cellular membranes, especially …

Influence of Nonspecific Interactions between Proteins and In Vivo Cytoplasmic Crowders in Facilitated Diffusion of Proteins: Theoretical Insights

B Punia, S Chaudhury - The Journal of Physical Chemistry B, 2022 - ACS Publications
The binding of proteins to their respective specific sites on the DNA through facilitated
diffusion serves as the initial step of various important biological processes. While this …

Acceleration of enzymatic reactions due to nearby inactive binding sites

H Katznelson, S Rahav - arXiv preprint arXiv:2501.01662, 2025 - arxiv.org
Many biological molecular motors and machines are driven by chemical reactions that occur
in specific catalytic sites. We study whether the arrival of molecules to such an active site can …

Surface-facilitated trapping by active sites: From catalysts to viruses

MM Misiura, AM Berezhkovskii, SM Bezrukov… - The Journal of …, 2021 - pubs.aip.org
Trapping by active sites on surfaces plays important roles in various chemical and biological
processes, including catalysis, enzymatic reactions, and viral entry into host cells. However …

[PDF][PDF] Stochastic modeling of protein target search in different DNA topologies

CF dos Anjos - 2022 - repository.rice.edu
The target search process in DNA is the very first step for very fundamental biochemical and
biophysical steps that follow. Gene transcription and formation of protein-DNA structures are …