Antibodies are essential to immune homeostasis due to their roles in neutralizing
pathogenic agents. However, failures in central and peripheral checkpoints that eliminate …

Immunotherapy profoundly changed the landscape of cancer therapy by providing long-
lasting responses in subsets of patients and is now the standard of care in several solid …

Highlights•Functional screens integrate with single cell BCR-sequencing and
transcriptomics.•Bottom-up and top-down MS enable comprehensive profiling of circulating …

The intricate relationship between anti-tumor immunity and autoimmunity is a complex yet
crucial aspect of cancer biology. Tumor microenvironment often exhibits autoimmune …

Immune cells in the tumor microenvironment play a crucial role in cancer prognosis and
response to immunotherapy. Recent studies highlight the significance of tumor-infiltrating B …

The immune repertoire (IR) is a term that defines the combined unique genetic
rearrangements of antigen receptors expressed by B and T lymphocytes. The IR determines …

Radiation-induced lymphopenia (RIL) is associated with worse outcomes in patients with
multiple solid tumors. Hypofractionated radiation therapy (HFRT) reduces RIL compared …

This study aims to rigorously explore the potential causal relationships among gut
microbiota (GM), immune cells, and melanoma skin cancer among participants from Europe …

Background The role of B cells in antitumor immunity remains controversial, with studies
suggesting the protumor and antitumor activity. This controversy may be due to the …

Melanoma is highly malignant and mainly occurs in the skin. Melanoma was first used in
immunotherapy due to its high immunogenicity, which changed the therapeutic pattern of …