[HTML][HTML] Mechanisms of resistance and treatment of relapse after CAR T-cell therapy for large B-cell lymphoma and multiple myeloma

K Rejeski, MD Jain, EL Smith - Transplantation and Cellular Therapy, 2023 - Elsevier
Although chimeric antigen receptor (CAR) T cell therapy (CAR-T) has altered the treatment
landscape for relapsed/refractory B cell malignancies and multiple myeloma, only a minority …

Failure of CAR-T cell therapy in relapsed and refractory large cell lymphoma and multiple myeloma: An urgent unmet need

YS Martin, JK Franz, ME Agha, HM Lazarus - Blood Reviews, 2023 - Elsevier
Since its FDA approval, chimeric antigen receptor (CAR)-T cell therapy is changing the
landscape of the treatment algorithm for relapsed and refractory large cell lymphoma and …

Recent bendamustine treatment before apheresis has a negative impact on outcomes in patients with large B-cell lymphoma receiving chimeric antigen receptor T-cell …

G Iacoboni, V Navarro, AÁ Martín-López… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE Approximately 30%-40% of patients with relapsed/refractory (R/R) large B-cell
lymphoma (LBCL) infused with CD19-targeted chimeric antigen receptor (CAR) T cells …

Second-line chimeric antigen receptor T-cell therapy in diffuse large B-cell lymphoma: a cost-effectiveness analysis

AH Kelkar, ERS Cliff, CA Jacobson… - Annals of Internal …, 2023 - acpjournals.org
Background: First-line treatment of diffuse large B-cell lymphoma (DLBCL) achieves durable
remission in approximately 60% of patients. In relapsed or refractory disease, only about …

[HTML][HTML] ASTCT clinical practice recommendations for transplantation and cellular therapies in diffuse large B cell lymphoma

N Epperla, A Kumar, SA Abutalib, FT Awan… - … and cellular therapy, 2023 - Elsevier
Autologous hematopoietic cell transplantation (auto-HCT) has long been the standard
approach for patients with relapsed/refractory (R/R) chemosensitive diffuse large B cell …

[HTML][HTML] Salvage radiotherapy in relapsed/refractory large B-cell lymphoma after failure of CAR T-cell therapy

HS Ababneh, AK Ng, MJ Frigault, JS Abramson… - …, 2023 - ncbi.nlm.nih.gov
Despite the success of CD19-targeted chimeric antigen receptor (CAR T)-cell therapy in
patients with relapsed/refractory large B-cell lymphoma (LBCL), there is a need for effective …

Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL

J Zurko, I Nizamuddin, N Epperla, K David… - Blood …, 2023 - ashpublications.org
Most patients receiving chimeric antigen receptor T-cell therapy (CAR-T) for aggressive B-
cell non-Hodgkin lymphoma (B-NHL) do not experience a durable remission. Several novel …

Therapeutic options for large B-cell lymphoma relapsing after CD19-directed CAR T-cell therapy

S El Warrak, MA Kharfan-Dabaja, M Iqbal… - Bone Marrow …, 2024 - nature.com
In recent years, chimeric antigen receptor T-cell therapy (CAR T) has revolutionized the
treatment landscape for large B cell lymphoma (LBCL), demonstrating remarkable efficacy …

Outcome after chimeric antigen receptor (CAR) T‐cell therapy failure in large B‐cell lymphomas

A Dodero, S Bramanti, M Di Trani… - British journal of …, 2024 - Wiley Online Library
This study retrospectively evaluated the outcome of salvage therapy in 51 patients who
failed axicabtagene ciloleucel or tisagenlecleucel for relapsed/refractory large B‐cell …

Relapsed or refractory large B‐cell lymphoma after chimeric antigen receptor T‐cell therapy: Current challenges and therapeutic options

R Del Toro‐Mijares, O Oluwole… - British Journal of …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR) T‐cell (CAR‐T) therapy can provide durable remission in
patients with relapsed or refractory diffuse large B‐cell lymphoma (DLBCL) after failure of …