Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions,
CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM) …

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for
many core tasks of this organelle. Its acyl chain configurations are tissue specific …

Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity
caused by mutations in TAFAZZIN (TAZ) that affect remodeling of mitochondrial cardiolipin …

A significant fraction of the glycerophospholipids in the human body is composed of
plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in …

Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …

Cristae are infoldings of the mitochondrial inner membrane jutting into the organelle's
innermost compartment from narrow stems at their base called crista junctions. They are …

Aging is a complex biological process characterized by a progressive decline in cellular and
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …

Barth Syndrome is a rare X‐linked disorder caused by pathogenic variants in the gene
TAFAZZIN, which encodes for an enzyme involved in the remodeling of cardiolipin, a …