Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer
The sphingosine-1-phosphate receptor 1 (S1PR1) radiotracer [11C] CS1P1 has shown
promise in proof-of-concept PET imaging of neuroinflammation in multiple sclerosis (MS) …
promise in proof-of-concept PET imaging of neuroinflammation in multiple sclerosis (MS) …
Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate
Here we report our design and synthesis of 28 new fluorine-containing compounds as
potential F-18 radiotracers for CNS imaging of sphingosine-1-phosphate receptor 1 …
potential F-18 radiotracers for CNS imaging of sphingosine-1-phosphate receptor 1 …
PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F] TZ4877 in Nonhuman Primates
Purpose The sphingosine-1-phosphate receptor-1 (S1PR 1) is involved in regulating
responses to neuroimmune stimuli. There is a need for S1PR 1-specific radioligands with …
responses to neuroimmune stimuli. There is a need for S1PR 1-specific radioligands with …