Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

Highlights•Identified as a master regulator of neuronal genes in embryogenesis, REST is a
common theme in neurodegeneration.•Whereas bioinformatics predicts∼ 2000 REST …

Fragile X syndrome (FXS) is the most frequent form of heritable intellectual disability and
autism. Fragile X (Fmr1-KO) mice exhibit aberrant dendritic spine structure, synaptic …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

The mechanisms generating epileptic neuronal networks following insults such as severe
seizures are unknown. We have previously shown that interfering with the function of the …

The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, autophagy,
translation, and survival. Dysregulation of mTOR signaling is associated with cancer …

Emergence of an aggressive androgen receptor (AR)-independent neuroendocrine prostate
cancer (NEPC) after androgen-deprivation therapy (ADT) is well-known. Nevertheless, the …

During neurogenesis, specific transcription factors are needed to repress neuronal genes in
nonneuronal cells to ensure precise development. Repressor element-1 binding …

Pyrvinium, a lipophilic cation belonging to the cyanine dye family, has been used in the
clinic as a safe and effective anthelminthic for over 70 years. Its structure, similar to some …

The Na+-Ca2+ exchanger 1 (NCX1) is reduced in stroke by the RE1-silencing transcription
factor (REST), whereas it is increased in ischemic brain preconditioning (PC) by hypoxia …