It has been widely held that all that fathers essentially contribute to the next generation is
half their genome. However, recent progress towards understanding biological processes …

Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

OBJECTIVE: To compare sperm characteristics among: patients undergoing infertility
evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with …

The profound architectural changes that transform spermatids into spermatozoa result in a
high degree of DNA packaging within the sperm head. However, the mature sperm …

The recent identification of RNA as a component of mature spermatozoa necessitated the
development of a reliable isolation protocol capable of yielding a high-quality substrate. In …

OBJECTIVE: To establish the stability of spermatozoal RNAs as a means to validate their
use as a male fertility marker. DESIGN: Semen samples were randomly selected for 1 of 3 …

The initial evaluation of the subfertile male includes a through history and physical
examination, semen analyses, and hormonal evaluation. However, a normal spermiogram …

To date, there has been little progress towards identifying markers of normal male fertility.
The need to supplement current subjective methods that rely on variable semen parameters …

The objective was to determine the association of mRNA expression of cystine rich secretary
protein 2 (CRISP2), chaperonin containing T-complex protein 1, subunit 8 (CCT8), and …

Spermatozoal maturation in the epididymis is dependent on proteins secreted by the
epithelium and those that create the proper ionic composition and pH of the lumen as well …