Termination of mRNA translation occurs when a stop codon enters the A site of the
ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a …

▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

Polypeptide Release Factors in Prokaryotes and Eukaryotes: Structure Skip to Main Content
Advertisement Structure This journal offers authors two options (open access or subscription) …

Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …

In this review, we provide an overview of protein synthesis in the yeast Saccharomyces
cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other …

Ten percent of inherited diseases are caused by premature termination codon (PTC)
mutations that lead to degradation of the mRNA template and to the production of a non …

Termination of translation in eukaryotes has focused recently on functional anatomy of
polypeptide chain release factor, eRF1, by using a variety of different approaches. The tight …

When a stop codon is at the 80S ribosomal A site, there are six nucleotides (+ 4 to+ 9)
downstream that are inferred to be occupying the mRNA channel. We examined the …

Translation termination in eukaryotes is mediated by two release factors, eRF1 and eRF3.
eRF1 recognizes each of the three stop codons (UAG, UAA, and UGA) and facilitates …