Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Many factors in the domains of mental, physical, and social health have been associated
with various ocular surface diseases, with most of the focus centered on aspects of dry eye …

Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory
nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …

The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

Background Dry eye disease (DED) is a multifactorial disease associated with ocular
surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central …

Purpose To describe the association between Sars-CoV-2 infection and small fiber
neuropathy in the cornea identified by in vivo corneal confocal microscopy. Methods Twenty …

Abstract Background and Purpose: Corneal injury can result in dysfunction of corneal
nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system …