Advances in Babesia Vaccine Development: An Overview

M Jerzak, A Gandurski, M Tokaj, W Stachera, M Szuba… - Pathogens, 2023 - mdpi.com
Babesiosis is a tick-borne zoonotic disease, which is caused by various species of
intracellular Babesia parasite. It is a problem not only for the livestock industry but also for …

A vaccine for human babesiosis: Prospects and feasibility

H Al-Nazal, LM Low, S Kumar, MF Good… - Trends in Parasitology, 2022 - cell.com
Babesiosis is a tick-borne disease caused by intraerythrocytic Babesia parasites. It is a well-
known illness in companion animals and livestock, resulting in substantial economic losses …

Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

HA Al-Nazal, E Cooper, MF Ho, S Eskandari… - Cell Host & Microbe, 2021 - cell.com
Babesia spp. are tick-transmitted intra-erythrocytic protozoan parasites that infect humans
and animals, causing a flu-like illness and hemolytic anemia. There is currently no human …

Protective efficacy and correlates of immunity of immunodominant recombinant Babesia microti antigens

S Meredith, V Majam, H Zheng, N Verma… - Infection and …, 2023 - Am Soc Microbiol
Babesia microti, an intraerythrocytic apicomplexan parasite, is the primary causative agent
of human babesiosis and an emerging threat to public health in the United States and …

Neospora GRA6 possesses immune-stimulating activity and confers efficient protection against Neospora caninum infection in mice

RM Fereig, N Shimoda, HH Abdelbaky, Y Kuroda… - Veterinary …, 2019 - Elsevier
Vaccination has the potential to be the most cost-effective control measure for reducing the
economic burden of neosporosis in cattle. In this study, the immune-stimulatory effect of …

Evaluation of a Major Surface Antigen of Babesia microti Merozoites as a Vaccine Candidate against Babesia Infection

S Man, Y Fu, Y Guan, M Feng, K Qiao, X Li… - Frontiers in …, 2017 - frontiersin.org
Babesia species are tick-borne intraerythrocytic protozoa that cause babesiosis in humans
worldwide. No vaccine has yet proven effective against Babesia infection. Surface antigens …

In Silico Survey and Characterization of Babesia microti Functional and Non-Functional Proteases

M Florin-Christensen, SN Wieser, CE Suarez… - Pathogens, 2021 - mdpi.com
Human babesiosis caused by the intraerythrocytic apicomplexan Babesia microti is an
expanding tick-borne zoonotic disease that may cause severe symptoms and death in …

Alternative and Complementary Approaches to Consider for Effective Babesia Vaccine Development

J Maye, A Cabezas-Cruz - Pathogens, 2023 - mdpi.com
The Babesia genus encompasses several species of apicomplexan hemoprotozoan
parasites. These parasites, primarily transmitted by ticks, have gained attention due to their …

Immunogenic composition

M Good, ALN Hanan, D Stanisic - US Patent App. 18/560,137, 2024 - Google Patents
DWQYILVVCVQOOR-UHFFFAOYSA-N [8-(chloromethyl)-4-hydroxy-7, 8-dihydrofuro [2, 3-e]
indol-6-yl]-(5, 6, 7-trimethoxy-1h-indol-2-yl) methanone Chemical compound N1C= 2C …