Optimizing oncolytic virotherapy in cancer treatment

K Harrington, DJ Freeman, B Kelly, J Harper… - Nature reviews Drug …, 2019 - nature.com
In the wake of the success of modern immunotherapy, oncolytic viruses (OVs) are currently
seen as a potential therapeutic option for patients with cancer who do not respond or fail to …

Integrating oncolytic viruses in combination cancer immunotherapy

PK Bommareddy, M Shettigar… - Nature Reviews …, 2018 - nature.com
Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target
multiple steps within the cancer–immunity cycle. Oncolytic viruses directly lyse tumour cells …

Oncolytic viruses and the immune system: the dynamic duo

AL De Matos, LS Franco, G McFadden - Molecular Therapy-Methods & …, 2020 - cell.com
Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach
toward cancer treatment. This therapy takes advantage of the natural propensity of most …

CAR T-cell therapy in hematological malignancies

T Haslauer, R Greil, N Zaborsky… - International Journal of …, 2021 - mdpi.com
Chimeric antigen receptor (CAR) T-cells (CAR T-cells) are a promising therapeutic approach
in treating hematological malignancies. CAR T-cells represent engineered autologous T …

[HTML][HTML] Oncolytic virus therapy in cancer: A current review

JS Apolonio, VL de Souza Gonçalves… - World journal of …, 2021 - ncbi.nlm.nih.gov
In view of the advancement in the understanding about the most diverse types of cancer and
consequently a relentless search for a cure and increased survival rates of cancer patients …

Oncolytic viral therapy and the immune system: a double-edged sword against cancer

G Marelli, A Howells, NR Lemoine, Y Wang - Frontiers in immunology, 2018 - frontiersin.org
Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs)
can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass …

Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics

ZS Guo, B Lu, Z Guo, E Giehl, M Feist, E Dai… - … for immunotherapy of …, 2019 - Springer
Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment

N Ghasemi Darestani, AI Gilmanova… - Cell Communication and …, 2023 - Springer
Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no
damage to normal cells in the process. Because of their specific features, such as, the ability …

[HTML][HTML] Harnessing the immune system to improve cancer therapy

NE Papaioannou, OV Beniata, P Vitsos… - Annals of …, 2016 - ncbi.nlm.nih.gov
Cancer immunotherapy uses the immune system and its components to mount an anti-tumor
response. During the last decade, it has evolved from a promising therapy option to a robust …

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

T Briolay, T Petithomme, M Fouet, N Nguyen-Pham… - Molecular cancer, 2021 - Springer
Background As a complement to the clinical development of new anticancer molecules,
innovations in therapeutic vectorization aim at solving issues related to tumor specificity and …