Parenteral nutrition (PN) has revolutionized the care of patients with intestinal failure by
providing nutrition intravenously. Worldwide, PN remains a standard tool of nutrition delivery …

Nutritional management is a cornerstone of therapy for patients who are critically ill. Data
show that enteral nutrition is better than parenteral nutrition with regard to the morbidity of …

Background and Aims The mammalian intestinal epithelium self-renews rapidly and
homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs …

Animals that undergo seasonal cycles of feeding and fasting have adaptations that maintain
integrity of organ systems when dietary nutrients are lacking. Food deprivation also …

Background & Aims Paneth cells secrete antimicrobial proteins including lysozyme via
secretory autophagy as part of the mucosal protective response. The ELAV like RNA-binding …

Intestinal Tuft cells sense luminal contents to influence the mucosal immune response
against eukaryotic infection. Paneth cells secrete antimicrobial proteins as part of the …

Intestinal resident macrophages (Mϕs) regulate gastrointestinal homeostasis via production
of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by …

The development of intestinal failure-associated liver disease (IFALD) in pediatric and adult
patients on parenteral nutrition is usually multifactorial in nature due to nutritional and non …

Parenteral nutrition (PN) dependence, while life sustaining, carries a significant risk of septic
complications associated with epithelial barrier dysfunction and translocation of gut‐derived …

Total parenteral nutrition (TPN) is a life‐saving therapy administered to millions of patients.
However, it is associated with significant adverse effects, namely liver injury, risk of …