[HTML][HTML] Breast cancer vaccines: New insights into immunomodulatory and nano-therapeutic approaches
Breast cancer (BC) is known to be a highly heterogeneous disease that is clinically
subdivided into four primary molecular subtypes, each having distinct morphology and …
subdivided into four primary molecular subtypes, each having distinct morphology and …
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control
C Lhuillier, NP Rudqvist, T Yamazaki… - The Journal of …, 2021 - Am Soc Clin Investig
Neoantigens generated by somatic nonsynonymous mutations are key targets of tumor-
specific T cells, but only a small number of mutations predicted to be immunogenic are …
specific T cells, but only a small number of mutations predicted to be immunogenic are …
Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression
P Sinha, VK Clements, S Miller… - Cancer Immunology …, 2005 - Springer
The mouse 4T1 mammary carcinoma is a BALB/c-derived tumor that spontaneously
metastasizes and induces immune suppression. Although> 95% of wild type BALB/c mice …
metastasizes and induces immune suppression. Although> 95% of wild type BALB/c mice …
Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based …
There are still some gaps in existing knowledge in the field of cancer nanotheranostics, eg.,
the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold …
the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold …
Mouse 4T1 breast tumor model
BA Pulaski… - Current protocols in …, 2000 - Wiley Online Library
The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic
and invasive and, unlike most tumor models, can spontaneously metastasize from the …
and invasive and, unlike most tumor models, can spontaneously metastasize from the …
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
S Demaria, N Kawashima, AM Yang, ML Devitt… - Clinical Cancer …, 2005 - AACR
Purpose: Ionizing radiation therapy (RT) is an important component in the management of
breast cancer. Although the primary tumor can be successfully treated by surgery and RT …
breast cancer. Although the primary tumor can be successfully treated by surgery and RT …
Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells
EM Hanson, VK Clements, P Sinha… - The Journal of …, 2009 - journals.aai.org
Effective cell-mediated antitumor immunity requires the activation of tumor-reactive T cells
and the trafficking of activated T cells to tumor sites. These processes involve the …
and the trafficking of activated T cells to tumor sites. These processes involve the …
CXCR4 regulates growth of both primary and metastatic breast cancer
The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
K Yamane, K Tateishi, RJ Klose, J Fang, LA Fabrizio… - Molecular cell, 2007 - cell.com
Posttranslational modification of chromatin by histone methylation has wide-ranging effects
on nuclear function, including transcriptional regulation, maintenance of genome integrity …
on nuclear function, including transcriptional regulation, maintenance of genome integrity …
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
E Cretney, K Takeda, H Yagita, M Glaccum… - The Journal of …, 2002 - journals.aai.org
We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate
immune surveillance against tumor development. In this study, we describe the use of TRAIL …
immune surveillance against tumor development. In this study, we describe the use of TRAIL …