The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …

The solid-phase methodology is key for an effective synthesis of peptides, from a milligram
scale for research to a multi-kilo scale for drug production. Indeed, small peptides containing …

Peptide thioesters play a key role in convergent protein synthesis strategies such as native
chemical ligation, traceless Staudinger ligation, and Ag+‐mediated thioester ligation. The …

A new method for the preparation of peptide thioester by the post-solid phase peptide
synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were …

This review describes the recent advances in the field of glycopeptide and small
glycoprotein synthesis. The strategies covered include chemical and chemoenzymatic …

A novel strategy to generate thioester peptides compatible with Fmoc chemistry is
presented. Peptide-Cαoxy-(2-mercapto-1-carboxyamide) ethyl ester undergoes an O to S …

With two β-mercaptoethyl groups on the N, a tertiary amide of structure 1 is always poised for
intramolecular thioesterification however it flips about the C− N bond. It is shown that a …

N→ S acyl-transfer-mediated synthesis of peptide thioesters utilizing an N-aminoacyl-N-
sulfanylethylaminobenzoic acid derivative has been examined. The developed synthetic …