The RE-AIM planning and evaluation framework was conceptualized two decades ago. As
one of the most frequently applied implementation frameworks, RE-AIM has now been cited …

In pragmatic trials, participants are broadly representative of people who will receive a
treatment or diagnostic strategy, and the outcomes affect day-to-day care. The authors …

Background The Medical Research Council published the second edition of its framework in
2006 on developing and evaluating complex interventions. Since then, there have been …

Ideally, questions about comparative effectiveness or safety would be answered using an
appropriately designed and conducted randomized experiment. When we cannot conduct a …

PRECIS is a tool to help trialists make design decisions consistent with the intended
purpose of their trial. This paper gives guidance on how to use an improved, validated …

Without a complete published description of interventions, clinicians and patients cannot
reliably implement interventions that are shown to be useful, and other researchers cannot …

Mixed methods research—ie, research that draws on both qualitative and quantitative
methods in varying configurations—is well suited to address the increasing complexity of …

In this first paper in a series of four papers on midwifery, we aimed to examine,
comprehensively and systematically, the contribution midwifery can make to the quality of …

Background Incurable cancer, which often constitutes an enormous challenge for patients,
their families, and medical professionals, profoundly affects the patient's physical and …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …