The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy
S Bhattacharya, BG Prajapati, S Singh - Critical Reviews in Oncology …, 2023 - Elsevier
Stimuli-responsive nanocarriers have the potential to revolutionize cancer treatment by
allowing precise delivery of drugs to the site of disease. The use of polymeric nanocarriers …
allowing precise delivery of drugs to the site of disease. The use of polymeric nanocarriers …
“Four-in-One” Nanozyme for Amplified Catalytic-Photothermal Therapy
Q Zhang, T Zhuang, X Sun, Y Bao, L Zhu… - Journal of Colloid and …, 2024 - Elsevier
The cancer therapeutic efficacy of the peroxidase (POD)-mimicking nanozyme-based
monotherapy is significantly hindered due to insufficient intratumoral hydrogen peroxide (H …
monotherapy is significantly hindered due to insufficient intratumoral hydrogen peroxide (H …
Multifunctional polyetheramine–epoxide gels and their prospective applications in health and agriculture
HE Andrada, BA Fico, FB Alves, JM Paulino… - New Journal of …, 2024 - pubs.rsc.org
In this work, nanogels based on polyetheramine–epoxide (PPO–DPEG) were developed,
and two potential envisions for the nanocarriers were explored, for the first time, as …
and two potential envisions for the nanocarriers were explored, for the first time, as …
Recent advances of multifunctional zwitterionic polymers for biomedical application
W Lv, Y Wang, H Fu, Z Liang, B Huang, R Jiang, J Wu… - Acta Biomaterialia, 2024 - Elsevier
Zwitterionic polymers possess equal total positive and negative charges in the repeating
units, making them electrically neutral overall. This unique property results in …
units, making them electrically neutral overall. This unique property results in …
Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads
Abstract Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to
their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often …
their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often …
Stimuli‐Responsive New Horizons for Biomedical Applications: Metal–Organic Framework‐Based Nanozymes
J Yan, Y Zhao, M Du, C Cui, Z Bai, Y Liu, L Sun… - Small …, 2024 - Wiley Online Library
Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained
considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency …
considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency …
Charge-Complementary Polymersomes for Enhanced mRNA Delivery
HS Kim, YR Ahn, M Kim, J Choi, SJ Shin, HO Kim - Pharmaceutics, 2023 - mdpi.com
Messenger RNA (mRNA) therapies have emerged as potent and personalized alternatives
to conventional DNA-based therapies. However, their therapeutic potential is frequently …
to conventional DNA-based therapies. However, their therapeutic potential is frequently …
DNA nanoflowers encapsulating horseradish peroxidase as a signal amplification tag for rapid diagnosis in cytology specimens
J Xiang, K Feng, T Wan, S He, H Deng, D Li - Microchemical Journal, 2024 - Elsevier
Rapid analysis of cytology samples obtained by minimally invasive sampling is essential in
clinical diagnosis, yet existing diagnostic methods are often cumbersome and time …
clinical diagnosis, yet existing diagnostic methods are often cumbersome and time …
Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen
ZG Han, K He, Y Zheng, L Qian - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Among the fastest-growing bio-pharmaceuticals, therapeutic antibodies have achieved
unprecedented success in treating various diseases. Though powerful, issues such as …
unprecedented success in treating various diseases. Though powerful, issues such as …