The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

Adolescence is a period of profound developmental changes, which run the gamut from
behavioral and neural to physiological and hormonal. It is also a time at which there is an …

Emerging preclinical and clinical evidence indicate that the lateral habenula plays a major
role in the pathophysiology of depressive illness. Aberrant increases in neuronal activity in …

Acute injections of ketamine lead to rapid but transient antidepressant effects. Chronic oral
treatment at low doses, a promising non-invasive alternative, may prolong this therapeutic …

Suicide is the second leading cause of death in the United States among individuals aged
10–24, and severe youth depression is often refractory to the current standards of care …

Background Ketamine's potent and rapid antidepressant properties have shown great
promise to treat severe forms of major depressive disorder (MDD). A recently hypothesized …

Depression is a complex and highly heterogeneous disorder which diagnosis is based on
an exceedingly variable set of clinical symptoms. Current treatments focus almost …

In this Perspective review, we highlight some of the less explored aspects of lateral
habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide …