The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment
L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver
diseases worldwide and can develop into various conditions, ranging from simple steatosis …
diseases worldwide and can develop into various conditions, ranging from simple steatosis …
Inflammasome-mediated inflammation in liver ischemia-reperfusion injury
MB Jiménez-Castro, ME Cornide-Petronio… - Cells, 2019 - mdpi.com
Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …
procedures including hepatic resection and liver transplantation, and represents the main …
Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages
W Zhong, Z Rao, J Rao, G Han, P Wang, T Jiang… - Aging cell, 2020 - Wiley Online Library
Although aggravated liver injury has been reported in aged livers post‐ischemia and
reperfusion (IR), the underlying mechanism of innate immune activation of aged …
reperfusion (IR), the underlying mechanism of innate immune activation of aged …
Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways
Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …
effective drugs with several pharmacological activities. Many valuable publications have …
Dexmedetomidine alleviates hepatic ischaemia‐reperfusion injury via the PI3K/AKT/Nrf2‐NLRP3 pathway
Y Wu, G Qiu, H Zhang, L Zhu, G Cheng… - Journal of cellular …, 2021 - Wiley Online Library
Hepatic ischaemia‐reperfusion (I/R) injury constitutes a tough difficulty in liver surgery.
Dexmedetomidine (Dex) plays a protective role in I/R injury. This study investigated …
Dexmedetomidine (Dex) plays a protective role in I/R injury. This study investigated …
The role of NLRP3 inflammasome-mediated pyroptosis in ischemic stroke and the intervention of traditional Chinese medicine
JX Long, MZ Tian, XY Chen, HH Yu, H Ding… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is the second leading cause of death and disability in the world.
Pyroptosis, a form of programmed cell death initiated by caspases, participates in the …
Pyroptosis, a form of programmed cell death initiated by caspases, participates in the …
The role of NF-κB triggered inflammation in cerebral ischemia
T Jover-Mengual, JY Hwang, HR Byun… - Frontiers in cellular …, 2021 - frontiersin.org
Cerebral ischemia is a devastating disease that affects many people worldwide every year.
The neurodegenerative damage as a consequence of oxygen and energy deprivation, to …
The neurodegenerative damage as a consequence of oxygen and energy deprivation, to …
Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis
X Xie, F Wang, X Li - Journal of Receptors and Signal Transduction, 2022 - Taylor & Francis
Purpose Many proteins in tripartite motif (TRIM) family have been reported to play an
important role in cerebral ischemia/reperfusion (I/R) injury. This study was designed to …
important role in cerebral ischemia/reperfusion (I/R) injury. This study was designed to …
Mangiferin for the Management of Liver Diseases: A Review
L Li, Y Dong, X Liu, M Wang - Foods, 2023 - mdpi.com
The liver is a digestive and metabolic organ, and several factors can induce liver damage,
which is a severe threat to human health. As a natural polyphenolic compound, mangiferin …
which is a severe threat to human health. As a natural polyphenolic compound, mangiferin …
Transcriptional changes in orthotopic liver transplantation and ischemia/reperfusion injury
Y Ma, C Wang, G Xu, X Yu, Z Fang, J Wang, M Li… - Transplant …, 2022 - Elsevier
Background There are few effective targeting strategies to reduce liver ischemia-reperfusion
injury (IRI), which is one of the reasons for the poor prognosis of liver transplant recipients …
injury (IRI), which is one of the reasons for the poor prognosis of liver transplant recipients …