Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

This article provides recommendations for implementing QSM for clinical brain research. It is
a consensus of the International Society of Magnetic Resonance in Medicine, Electro …

Quantitative susceptibility mapping (QSM) and effective transverse relaxation rate (R2*)
mapping are both highly sensitive to variations in brain iron content. Clinical Magnetic …

The brain tissue phase contrast in MRI sequences reflects the spatial distributions of multiple
substances, such as iron, myelin, calcium, and proteins. These substances with …

A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an …

Although multiple sclerosis has traditionally been considered a white matter disease,
extensive research documents the presence and importance of grey matter injury including …

Purpose To study deep gray matter susceptibility in multiple sclerosis (MS) by using
quantitative susceptibility mapping (QSM) and to assess the relationship between …

Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white
matter. Both cortical and deep gray matter injury is observed during the course of MS …

Quantitative susceptibility mapping (QSM) has gained broad interest in the field by extracting
bulk tissue magnetic susceptibility, predominantly determined by myelin, iron and calcium …